UniProt identifies TNFRSF1A as an established receptor for TNF.
ABMIUM target intelligence
TNF receptor superfamily member 1A
TNF receptor superfamily member 1A (TNFRSF1A), commonly called TNF receptor 1 (TNFR1) or CD120a, is a receptor for tumor necrosis factor. This ABMIUM record links NCBI Gene 7132 and UniProtKB P19438 to catalogue-backed research products.
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Names used across publications, databases and supplier catalogues.
TNF receptor superfamily member 1A (TNFRSF1A/TNFR1/CD120a) binds TNF and lymphotoxin-alpha. Receptor signalling can activate inflammatory and cell-survival pathways and, through its intracellular death domain and adaptor complexes, can also initiate caspase-dependent apoptosis.
TNFRSF1A/TNFR1 is studied in TNF signalling, inflammation, cell survival, programmed cell death and TNF-receptor biology. Review the linked ABMIUM research products and confirm species, sample type, application, assay format and product-level validation before use.
Interaction context
Explore biologically relevant proteins connected to TNFRSF1A through receptor complexes, pathway context, curated molecular relationships or database-supported functional evidence. Each relationship should be interpreted independently and does not establish reagent suitability.
UniProt identifies TNFRSF1A as an established receptor for TNF.
UniProt reports recruitment and interaction of the adaptor TRADD with activated TNFRSF1A.
UniProt reports TNF-dependent recruitment of RIPK1 to TNFRSF1A signalling complexes.
UniProt describes FADD recruitment in the TNFRSF1A death-signalling pathway.
Interpretation: Identity, aliases and biological context were checked against NCBI Gene 7132 and reviewed UniProtKB P19438 on 2026-08-17. Catalogue association does not establish suitability for a specific experiment; confirm product-level validation and sample compatibility.