Human TNFsR I ELISA Kit PicoKine®

Human TNFsR I ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFRSF1A in cell culture supernatants, serum, plasma ( heparin, EDTA, citrate) and urine. Sensitivity: 1pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

TNFsRI (also known as Solube tumor necrosis factor receptor 1) is a cytokine receptor that binds tumor necrosis factors (TNF). In contrast, the p60 (TNFRSF1A) and p80 (TNFRSF1B) TNFA receptors self-assemble through a distinct functional domain in the TNFR extracellular domain, termed the pre-ligand assembly domain (PLAD), in the absence of ligand. Deletion of the PLAD results in monomeric presentation of p60 or p80. Flow cytometric analysis showed that efficient TNFA binding depends on receptor self-assembly. They also found that other members of the TNF receptor superfamily, including the extracellular domains of TRAIL (TNFRSF10A), CD40, and FAS (TNFRSF6), all self-associate but do not interact with heterologous receptors. By Southern blot analysis of human/Chinese hamster somatic cell hybrid DNA, the TNFR1 gene was mapped to 12pter-cen. And by nonradioactive in situ hybridization that the type 1 receptor (the p55 TNF receptor) is encoded by a gene located on chromosome 12p13.2.

Product information

Supplier	Boster Bio
ABMIUM evidence status	ABMIUM Verified™ collaborator-tested data
Catalogue reference	EK0528
Product category	PicoKine® ELISA Kits
Reactive species	Human
Tested applications	ELISA
Gene name	TNFRSF1A
Protein name	Tumor necrosis factor receptor superfamily member 1A
Sample type	cell culture supernatants, serum, plasma ( heparin, EDTA, citrate) and urine.
Assay range	7.8 pg/ml - 500 pg/ml
Sensitivity	<1 pg/ml
Specificity	Natural and recombinant human TNFsRⅠ
Immunogen	Expression system for standard: NS0; Immunogen sequence: L30-T211
Storage	Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
UniProt	P19438
NCBI Gene ID	7132

Available variants

Conjugation	Size
Not applicable	96 wells/kit, with removable strips.