ATG7 Rabbit pAb from ELK Biotechnology
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ATG7 Rabbit pAb is a research-use antibody from ELK Biotechnology for studying ATG7 in IHC workflows with listed reactivity for Human, Mouse, Rat. Specifications and supporting documents below should be reviewed when planning the experiment.
The molecular machinery of autophagy was largely discovered in yeast and referred to as autophagy-related (Atg) genes. Formation of the autophagosome involves a ubiquitin-like conjugation system in which Atg12 is covalently bound to Atg5 and targeted to autophagosome vesicles. This conjugation reaction is mediated by the ubiquitin E1-like enzyme Atg7 and the E2-like enzyme Atg10.
| Validation evidence captions | Immunohistochemical analysis of paraffin-embedded Human Hepatocarcinoma Tissue using ATG7 （EA351）Rabbit pAb diluted at 1:200 | Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using ATG7 （EA351）Rabbit pAb diluted at 1:200. |
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Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Mouse | |||||||
| Rat |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
ATG7 (autophagy related 7) encodes ubiquitin-like modifier-activating enzyme ATG7, an E1-like enzyme that drives the ATG12-ATG5 and ATG8/LC3 conjugation systems required for autophagosome formation. ABMIUM catalogue products linked below target ATG7; suitability remains product- and application-specific.
Biological function: ATG7 acts as the E1-like activating enzyme for two core autophagy conjugation pathways. It activates ATG12 for conjugation to ATG5 and activates ATG8-family proteins for phosphatidylethanolamine conjugation, supporting LC3 lipidation and autophagosomal membrane formation. Reviewed UniProt also supports a role in mitophagy and mitochondrial quality control.
