ABMIUM target intelligence
autophagy related 7
ATG7 (autophagy related 7) encodes ubiquitin-like modifier-activating enzyme ATG7, an E1-like enzyme that drives the ATG12-ATG5 and ATG8/LC3 conjugation systems required for autophagosome formation. ABMIUM catalogue products linked below target ATG7; suitability remains product- and application-specific.
Read full target overview![Anti-Human/Mouse/Rat ATG7 Antibody [B721] - ABMIUM](http://www.abmium.com/cdn/shop/files/dxoV1nr4.jpg?v=1781565281&width=520)
![Anti-Human/Mouse/Rat ATG7 Antibody [1A1]](http://www.abmium.com/cdn/shop/files/KibTuT.jpg?v=1788967482&width=520)
Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
ATG7 acts as the E1-like activating enzyme for two core autophagy conjugation pathways. It activates ATG12 for conjugation to ATG5 and activates ATG8-family proteins for phosphatidylethanolamine conjugation, supporting LC3 lipidation and autophagosomal membrane formation. Reviewed UniProt also supports a role in mitophagy and mitochondrial quality control.
ATG7 is studied in macroautophagy, LC3/ATG8 lipidation, autophagosome biogenesis, mitophagy and stress-adaptation experiments. Interpretation can depend on nutrient state, autophagic flux, cell type and assay endpoint, so researchers should match species, application, epitope and product-level validation to the experimental design.
Names used across publications, databases and supplier catalogues.
