WZB117 is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibited cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC 50 of approximately 10 µM. Daily intraperitoneal injection of WZB117 at 10mg/kg resulted in 70% reduction in tumor volume of human A549 lung...
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WZB117 is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibited cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC 50 of approximately 10 µM. Daily intraperitoneal injection of WZB117 at 10mg/kg resulted in 70% reduction in tumor volume of human A549 lung cancer mouse xenografts. Blocked LPS-induced pulmonary expression of NLRP3 and GLUT1 and significantly attenuated lung tissue damage, neutrophil accumulation, and release of proinflammatory cytokines in mice
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SLC2A1 identifies solute carrier family 2 member 1 in Homo sapiens (Human). This target record connects NCBI Gene 6513, UniProtKB P11166 and related ABMIUM catalogue products.
