PARP inhibitor selective for PARP-2 (IC50=0.3 μM; ~ 27-fold selective against PARP-1). Increases apoptosis in hippocampal slices but protects cortical cells in models of post-ischemic brain damage. Blocks the interaction between PARP-2 and FOXA1, attenuating androgen receptor-mediated gene...
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PARP inhibitor selective for PARP-2 (IC50=0.3 μM; ~ 27-fold selective against PARP-1). Increases apoptosis in hippocampal slices but protects cortical cells in models of post-ischemic brain damage. Blocks the interaction between PARP-2 and FOXA1, attenuating androgen receptor-mediated gene expression and inhibiting androgen receptor-positive prostate cancer growth
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