Neuroregenerative and neuroprotective agent acting at components of the mitochondrial permeability transition pore (MPTP). Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in mice. Reduces ROS and NLRP3 inflammasome activation in...
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Neuroregenerative and neuroprotective agent acting at components of the mitochondrial permeability transition pore (MPTP). Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in mice. Reduces ROS and NLRP3 inflammasome activation in a mouse model of intracerebral hemorrhage. Inhibits MPTP opening and protects neurons from apoptosis. Induces oligodendrocyte maturation in culture and promotes myelin regeneration in vivo in a rodent model
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