Broad-spectrum imidazole antifungal used for the treatment of various skin infections. It inhibits the cytochrome P450 isozyme, C-14-alpha demethylase, preventing ergosterol synthesis. Sulconazole inhibited mammosphere formation, reduced NF-kB, and reduced extracellular IL-8 formation in breast...
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Broad-spectrum imidazole antifungal used for the treatment of various skin infections. It inhibits the cytochrome P450 isozyme, C-14-alpha demethylase, preventing ergosterol synthesis. Sulconazole inhibited mammosphere formation, reduced NF-kB, and reduced extracellular IL-8 formation in breast cancer cells leading to inhibition of cancer stem cell formation. It has a similar effect on glioma stem cells
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