Adenylate cyclase 1 inhibitor; Analgesic activity A novel selective adenylyl cyclase 1 (AC1) inhibitor, IC 50 =2.3 μM . Inhibits calcium 2+ -stimulated cAMP accumulation in HEK cells stably transfected with AC1. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors...
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Adenylate cyclase 1 inhibitor; Analgesic activity
A novel selective adenylyl cyclase 1 (AC1) inhibitor, IC 50 =2.3 μM . Inhibits calcium 2+ -stimulated cAMP accumulation in HEK cells stably transfected with AC1. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation. Displays analgesic properties in a mouse model of inflammatory pain
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