Inhibitor of separase (a cysteine protease that triggers chromosome segregation during mitosis and is highly overexpressed in many cancers), but not the related protease caspase-1, in vitro. HeLa cells with dysregulated separase activity showed severe chromosome segregation defects on treatment...
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Inhibitor of separase (a cysteine protease that triggers chromosome segregation during mitosis and is highly overexpressed in many cancers), but not the related protease caspase-1, in vitro. HeLa cells with dysregulated separase activity showed severe chromosome segregation defects on treatment with 30 µM SIC5-6 indicating a potential attractive new chemotherapeutic target
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