Potent Apoptosis signal-regulating kinase 1 (ASK1) inhibitor (pIC50 = 8.3) found to improve metabolic parameters in nonalcoholic steatohepatitis, reduce hepatic steatosis, inflammation, and fibrosis. Selonsertib suppressed the efflux function of multidrug resistance (MDR) transporters ABCB1 and...
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Potent Apoptosis signal-regulating kinase 1 (ASK1) inhibitor (pIC50 = 8.3) found to improve metabolic parameters in nonalcoholic steatohepatitis, reduce hepatic steatosis, inflammation, and fibrosis. Selonsertib suppressed the efflux function of multidrug resistance (MDR) transporters ABCB1 and ABCG2
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