Akt activator. Binds to the pleckstrin homology domain of Akt preventing membrane translocation but paradoxically activating it in the cytosol. Enhances Akt phosphorylation by upstream protein kinases. Suppresses excitotoxicity-induced neuronal death in vitro and in vivo. A useful tool for...
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Akt activator. Binds to the pleckstrin homology domain of Akt preventing membrane translocation but paradoxically activating it in the cytosol. Enhances Akt phosphorylation by upstream protein kinases. Suppresses excitotoxicity-induced neuronal death in vitro and in vivo. A useful tool for studying the PI3K/Akt axis
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AKT serine/threonine kinase 1 (AKT1), also known as protein kinase B alpha (PKB alpha), is a PI3K-regulated signalling kinase. This ABMIUM record links human AKT1 (NCBI Gene 207; UniProt P31749) to catalogue-backed research products.
Biological function: AKT1 is a serine/threonine kinase activated downstream of phosphoinositide 3-kinase signalling. It integrates growth-factor and receptor signals that regulate cell survival, proliferation, metabolism and angiogenic responses.
