Potent and selective CXCR2 receptor antagonist (IC50 = 22 nM). Displays >150-fold selectivity over CXCR1 receptors. Induces apoptosis in both wild-type and p53-deficient ovarian cancer cells (OVCA) via p53 activation and by inducing mitotic catastrophe. Blocks IL-8-mediated cellular effects such...
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Potent and selective CXCR2 receptor antagonist (IC50 = 22 nM). Displays >150-fold selectivity over CXCR1 receptors. Induces apoptosis in both wild-type and p53-deficient ovarian cancer cells (OVCA) via p53 activation and by inducing mitotic catastrophe. Blocks IL-8-mediated cellular effects such as oxidative stress-induced cellular senescence and neutrophil chemotaxis1. Inhibits HIV replication in lymphocytes and macrophages. Inhibits endothelial activation and leukocyte recruitment to cerebral microvessels during neuroinflammation
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CXCR2 identifies C-X-C motif chemokine receptor 2 in Homo sapiens (Human). This target record connects NCBI Gene 3579, UniProtKB P25025 and related ABMIUM catalogue products.
