Potent, irreversible monoamine oxidase (MAO) inhibitor selective for MAO-B (IC50=4.43 nM) over MAO-A (IC50=412 nM). Parkinson’s disease therapeutic. Displays neuroprotective and neurorestorative properties in a Parkinson’s disease zebrafish model. Prevents α-synuclein-induced dopaminergic...
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Potent, irreversible monoamine oxidase (MAO) inhibitor selective for MAO-B (IC50=4.43 nM) over MAO-A (IC50=412 nM). Parkinson’s disease therapeutic. Displays neuroprotective and neurorestorative properties in a Parkinson’s disease zebrafish model. Prevents α-synuclein-induced dopaminergic neuronal death and rescues TrkB neurotrophic signaling. Enhances BDNF levels and is neuroprotective in Parkinson’s disease models
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