R-59022 is a diacylglycerol kinase (DAGK) inhibitor, nonselective for DAGK isotypes (IC50=2.8 µM in intact platelets). Induces autophagy and apoptosis in NG108-15 neuronal cells via an mTOR-independent mechanism. Prevents conjugated linoleic acid-mediated inflammatory signaling and insulin...
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R-59022 is a diacylglycerol kinase (DAGK) inhibitor, nonselective for DAGK isotypes (IC50=2.8 µM in intact platelets). Induces autophagy and apoptosis in NG108-15 neuronal cells via an mTOR-independent mechanism. Prevents conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes. Blocks filovirus internalization in host cells
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