Inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts via binding to the inactivated form of MEK, preventing its phosphorylation by cRAF or MEK kinase (IC50=2-7μM). Accelerates differentiation of RAW264.7 cells into osteoclast-like cells. Mimics BMP4 in supporting self renewal...
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Inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts via binding to the inactivated form of MEK, preventing its phosphorylation by cRAF or MEK kinase (IC50=2-7μM). Accelerates differentiation of RAW264.7 cells into osteoclast-like cells. Mimics BMP4 in supporting self renewal of embryonic stem cells
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MDK identifies midkine in Homo sapiens (Human). This target record connects NCBI Gene 4192, UniProtKB P21741 and related ABMIUM catalogue products.
