Competitively inhibits DNA-dependent protein kinase (DNA-PK) (IC50 = 13 nM) over related kinases (IC50s 1.7 – 100 µM for mTOR, PI3K, ATM, and ATR). Sensitizes human colon cancer cells to etoposide and ionizing radiation through inhibition of double strand break repair of DNA. Enhances ionizing...
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Competitively inhibits DNA-dependent protein kinase (DNA-PK) (IC50 = 13 nM) over related kinases (IC50s 1.7 – 100 µM for mTOR, PI3K, ATM, and ATR). Sensitizes human colon cancer cells to etoposide and ionizing radiation through inhibition of double strand break repair of DNA. Enhances ionizing radiation-induced G2/M arrest of SUNE-1 cancer cells. Reverses acquired resistance to EGFR TK inhibitor osimertinib in a NSCLC line. Causes immunosuppression via reduction in cytokines and NFκB activity
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