Dynamin I/II inhibitor targeting the dynamin-phospholipid interaction and inhibiting dynamin GTPase activity with a Ki=940nM. Rapidly and reversibly inhibits multiple forms of endocytosis with no acute cellular damage. A useful pharmacological tool for studying dynamin-mediated trafficking...
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Dynamin I/II inhibitor targeting the dynamin-phospholipid interaction and inhibiting dynamin GTPase activity with a Ki=940nM. Rapidly and reversibly inhibits multiple forms of endocytosis with no acute cellular damage. A useful pharmacological tool for studying dynamin-mediated trafficking events. Induces cytokinesis failure and apoptosis in human cancer cells. Induces cytoprotective autophagy in human Jurkat T cells
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