MF-438 is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) – IC50 = 2.3 nM. MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and mg/kg). Cancer initiating cells (CSC-like) were shown to much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally...
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MF-438 is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) – IC50 = 2.3 nM. MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and mg/kg). Cancer initiating cells (CSC-like) were shown to much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model. MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models
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