Ferroptosis inhibitor (IC50 = 22 nM) that mitigates tissue injury in a mouse model of hepatic ischemia/reperfusion injury. It protected mouse myocardium against ischemia/reperfusion injury via a decrease in VDAC1 and restoration of GPX4 levels. Liproxstatin-1’s mechanism of activity has been...
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Ferroptosis inhibitor (IC50 = 22 nM) that mitigates tissue injury in a mouse model of hepatic ischemia/reperfusion injury. It protected mouse myocardium against ischemia/reperfusion injury via a decrease in VDAC1 and restoration of GPX4 levels. Liproxstatin-1’s mechanism of activity has been attributed to its activity as a radical-trapping antioxidant
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