Ketoconazole is a broad spectrum antifungal agent which acts via inhibition of a cytochrome P450, CYP51A1 which is a lanosterol 14α-demethylase. Also inhibits CYP3A and CYP1A1. Inhibits adrenal steroidogenesis. Downregulates cholesterol synthesis in drug-tolerant human lung cancer cell lines....
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Ketoconazole is a broad spectrum antifungal agent which acts via inhibition of a cytochrome P450, CYP51A1 which is a lanosterol 14α-demethylase. Also inhibits CYP3A and CYP1A1. Inhibits adrenal steroidogenesis. Downregulates cholesterol synthesis in drug-tolerant human lung cancer cell lines. Blocks the biosynthesis of leukotrienes (LT) via inhibition of 5-lipoxygenase and dose dependently inhibits LT-mediated bronchoconstriction in guinea pigs
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