Selective inhibitor of Usp14 (IC50<4 μM). Enhances proteasome activity and substrate proteolysis. Inhibits Dengue virus replication. In prion-infected CAD5 cells activation of the ubiquitin proteasome system by IU1 is sufficient to induce clearance of polyubiquitinated substrates and reduce...
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Selective inhibitor of Usp14 (IC50<4 μM). Enhances proteasome activity and substrate proteolysis. Inhibits Dengue virus replication. In prion-infected CAD5 cells activation of the ubiquitin proteasome system by IU1 is sufficient to induce clearance of polyubiquitinated substrates and reduce misfolded prion protein load. Attenuates ischemia/reperfusion-induced neuronal injury in a mouse model. Cell permeable
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