A potent and selective inhibitor of glycogen synthase kinase 3β (GSK-3β) IC50=53 nM which induces neuronal differentiation. Activates the Wnt-β-catenin signaling pathway and attenuates tissue plasminogen activator-induced hemorrhagic transformation after acute ischemic stroke in animal models....
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A potent and selective inhibitor of glycogen synthase kinase 3β (GSK-3β) IC50=53 nM which induces neuronal differentiation. Activates the Wnt-β-catenin signaling pathway and attenuates tissue plasminogen activator-induced hemorrhagic transformation after acute ischemic stroke in animal models. Promoted hair follicle growth in vitro and antagonized the inhibition of hair follicles by dihydrotestosterone. Down-regulates Sox9 expression in limbal epithelial stem/progenitor cells leading to increased differentiation
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