A lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types. Augments the anticancer activity of DNA-damaging chemotherapy. Antiinflammatory activity. Decreases cell surface expression of TNFα receptors in U937 cells. Has been used to treat alopecia...
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A lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types. Augments the anticancer activity of DNA-damaging chemotherapy. Antiinflammatory activity. Decreases cell surface expression of TNFα receptors in U937 cells. Has been used to treat alopecia successfully. Clinically useful antimalaria agent. Cell permeable and active in vivo
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