Potent allosteric inhibitor of WIP1 phosphatase (IC50 = 6 nM), a negative regulator of the DNA damage response. It displayed no inhibition of 21 other phosphatases. Active in xenograft model DoHH2 B-cell lymphoma. GSK2830371 in combination with MDM2 inhibitors has been shown to be efficacious in...
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Potent allosteric inhibitor of WIP1 phosphatase (IC50 = 6 nM), a negative regulator of the DNA damage response. It displayed no inhibition of 21 other phosphatases. Active in xenograft model DoHH2 B-cell lymphoma. GSK2830371 in combination with MDM2 inhibitors has been shown to be efficacious in the treatment of various cancers including liver adenocarcinoma, acute myeloid leukemia, and breast. It enhances phosphorylation of the tumor suppressor p53 leading to activation
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