Inhibits ‘master kinase’ PDK1 (3-phosphoinositide-dependent protein kinase, PDPK1), potently (IC50 = 10 nM) and specifically (5 µm does not inhibit even closely related kinases). GSK2334470 thus blocks activation of protein kinases (PK) A, G, and C, and further downstream, Akt, S6K, and mTORC1....
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Inhibits ‘master kinase’ PDK1 (3-phosphoinositide-dependent protein kinase, PDPK1), potently (IC50 = 10 nM) and specifically (5 µm does not inhibit even closely related kinases). GSK2334470 thus blocks activation of protein kinases (PK) A, G, and C, and further downstream, Akt, S6K, and mTORC1. Inhibits ferroptosis, and shows antitumor activity in multiple myeloma, prostate, and other cancers
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