GRL-0617 is a noncovalent inhibitor of the protease PLpro (papain-like protease; Nsp3) encoded by coronaviruses SARS-CoV (EC50 = 15 µM in Vero cells) and COVID-19 SARS-CoV-2 (EC50 = 28 µM in Vero cells), with no cytotoxicity. Although it was identified in a screen using a fluorescent peptide...
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GRL-0617 is a noncovalent inhibitor of the protease PLpro (papain-like protease; Nsp3) encoded by coronaviruses SARS-CoV (EC50 = 15 µM in Vero cells) and COVID-19 SARS-CoV-2 (EC50 = 28 µM in Vero cells), with no cytotoxicity. Although it was identified in a screen using a fluorescent peptide substrate comprising the 5 C-terminal residues of ubiquitin, it does not inhibit human deubiquitinating enzymes HAUSP, USP18, UCH-L1, UCH-L3, or PLP2
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