Ganetespib is an inhibitor of heat shock protein 90 (IC50 = 19 nM, canine C2 malignant mast cells; 4 nM, canine BR malignant mast cells) binding to the N-terminal ATP site. It displayed potent cytotoxicity against a panel of 57 transformed cell lines of both hematologic and solid tumors with...
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Ganetespib is an inhibitor of heat shock protein 90 (IC50 = 19 nM, canine C2 malignant mast cells; 4 nM, canine BR malignant mast cells) binding to the N-terminal ATP site. It displayed potent cytotoxicity against a panel of 57 transformed cell lines of both hematologic and solid tumors with IC50’s between 14 and 280 nM. Ganetespib enhanced T-cell-mediated killing of human melanoma cells and potentiated responses to anti-CTLA4 and anti-PD1 therapy via upregulation of interferon response genes. In multiple clinical trials for various cancers
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