Epacadostat is a potent (IC50 = 10nM) and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1) with no activity at IDO2 or TDO. It restored tryptophan levels and significantly impaired kynurenine generation in CT26 colon carcinoma (IC50 = 76 nM) and PAN02 pancreatic carcinoma (IC50 = 27...
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Epacadostat is a potent (IC50 = 10nM) and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1) with no activity at IDO2 or TDO. It restored tryptophan levels and significantly impaired kynurenine generation in CT26 colon carcinoma (IC50 = 76 nM) and PAN02 pancreatic carcinoma (IC50 = 27 nM) cells. Epacadostat increases the number and activity of tumor-infiltrating lymphocytes as well as increasing the ratio of effector T cells to regulatory T cells. Because of these immune system enhancing properties, it is being investigated as a synergistic agent for use with other immuno-oncology agents such as anti-PD-1 and anti-CTL4 antibodies
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
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IDO1 identifies indoleamine 2,3-dioxygenase 1 in Homo sapiens (Human). This target record connects NCBI Gene 3620, UniProtKB P14902 and related ABMIUM catalogue products.
