Selective α2-adrenergic receptor antagonist (selectivity ratio of α2/α1 = 724) and imidazoline receptor antagonist. Induces release of insulin in the rat insulinoma cell line RIN-5AH by interaction with ATP-sensitive potassium channels independently from imidazoline I 1 or I 2 receptors....
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Selective α2-adrenergic receptor antagonist (selectivity ratio of α2/α1 = 724) and imidazoline receptor antagonist. Induces release of insulin in the rat insulinoma cell line RIN-5AH by interaction with ATP-sensitive potassium channels independently from imidazoline I 1 or I 2 receptors. Increases resting plasma insulin levels and markedly potentiates the rise in insulin levels produced by adrenaline in the rat
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