Potent activator of Nrf2 target transcription via interaction with thiol groups of Keap1, an Nrf2 partner, in phase 2 response against oxidative stress. Inhibits the NF-κB pathway via inhibition of IKKα activation in vitro and reduces expression of proinflammatory cytokines in vivo. Alters tumor...
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Potent activator of Nrf2 target transcription via interaction with thiol groups of Keap1, an Nrf2 partner, in phase 2 response against oxidative stress. Inhibits the NF-κB pathway via inhibition of IKKα activation in vitro and reduces expression of proinflammatory cytokines in vivo. Alters tumor microenvironment causing breast tumor associated macrophages to switch from tumor-promoting to tumor-inhibiting characteristics in vitro. Reduces cancer stem cell marker expression in Ec109 and KYSE70 cells
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NFE2L2 identifies NFE2 like bZIP transcription factor 2 in Homo sapiens (Human). This target record connects NCBI Gene 4780, UniProtKB Q16236 and related ABMIUM catalogue products.
