BX795, originally described as a moderately potent inhibitor of PDK1 (IC50 = 111 nM), is, more importantly, a dual inhibitor of TBK1 and IKKε (IC50’s = 6 and 41 nM respectively). TBK1 and IKKε regulate the production of Type I interferons during bacterial and viral infection via phosphorylation...
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BX795, originally described as a moderately potent inhibitor of PDK1 (IC50 = 111 nM), is, more importantly, a dual inhibitor of TBK1 and IKKε (IC50’s = 6 and 41 nM respectively). TBK1 and IKKε regulate the production of Type I interferons during bacterial and viral infection via phosphorylation of the transcription factor IRF. It also inhibited of MARK, MLK, NUAK, AurB, and ERK8.3 BX795 exhibited antitumor activity in human oral squamous cell carcinoma, pancreatic ductal adenocarcinoma, and Glioblastoma Multiforme. BX795 has been used to enhance lentiviral transduction efficiency in human NK cells and human primary T cells for CAR-T cell therapy
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