BT2 is an inhibitor of the mitochondrial branched-chain α-ketoacid dehydrogenase complex kinase (BCKDC) – IC50 = 3.19 µM. Inhibition of this kinase has been shown to reduce levels of branched-chain amino acid concentrations in vivo. BT2 has also been shown to be a moderate inhibitor (Ki = 59 µM)...
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BT2 is an inhibitor of the mitochondrial branched-chain α-ketoacid dehydrogenase complex kinase (BCKDC) – IC50 = 3.19 µM. Inhibition of this kinase has been shown to reduce levels of branched-chain amino acid concentrations in vivo. BT2 has also been shown to be a moderate inhibitor (Ki = 59 µM) of myeloid cell leukemia 1(Mcl 1), a Bcl-2 family protein
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