TRPA1 channel blocker IC50=3.1-4.5 µM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. Does not block TRPV1, V2, V3, V4 or M8 at concentrations up to 50 µM. Blocks...
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TRPA1 channel blocker IC50=3.1-4.5 µM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. Does not block TRPV1, V2, V3, V4 or M8 at concentrations up to 50 µM. Blocks TRPA1 pore dilation (IC50=10.3 µM). An important tool for assessing the role of TRPA1 in cell signaling and physiological processes
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