A potent, cell-permeable Epac (exchange protein directly activated by cAMP) activator. Induces RAP1 activation and insulin secretion in pancreatic beta cell lines. Induces vascular relaxation in rat mesenteric artery. The acetoxymethyl ester confers increased cell-permeability and is cleaved by...
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A potent, cell-permeable Epac (exchange protein directly activated by cAMP) activator. Induces RAP1 activation and insulin secretion in pancreatic beta cell lines. Induces vascular relaxation in rat mesenteric artery. The acetoxymethyl ester confers increased cell-permeability and is cleaved by endogenous esterases to yield the active compound, 8-pCPT-2′-O-Me-cAMP. Addition to cell cultures should be done in serum-free media as esterases in serum will cleave the acetoxymethyl ester and reduce cell permeability
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