Inhibitor of ribozyme self-cleavage in mammalian cells. Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms besides global inhibition of RNA synthesis and processing contribute to 5-fluorouridine cytotoxicity. Cell permeable...
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Inhibitor of ribozyme self-cleavage in mammalian cells. Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms besides global inhibition of RNA synthesis and processing contribute to 5-fluorouridine cytotoxicity. Cell permeable and active in vivo
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