Inhibits c-Myc by disrupting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity. 10074-G5 binds to the c-Myc bHLHZip domain with Kd=2.8 µM1. It was cytotoxic in c-Myc-overexpressing cell lines (IC50s = 13 to 15 µM) but was not active in vivo due to rapid metabolism....
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Inhibits c-Myc by disrupting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity. 10074-G5 binds to the c-Myc bHLHZip domain with Kd=2.8 µM1. It was cytotoxic in c-Myc-overexpressing cell lines (IC50s = 13 to 15 µM) but was not active in vivo due to rapid metabolism. 10074-G5 is a useful tool to probe for involvement of c-Myc involvement in cellular processes. Binds to and sequesters the intrinsically disordered amyloid-β (Aβ) in its monomeric soluble state and rescues a C. elegans model of Aβ-associated toxicity
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MYC identifies MYC proto-oncogene, bHLH transcription factor in Homo sapiens (Human). This target record connects NCBI Gene 4609, UniProtKB P01106 and related ABMIUM catalogue products.
