PCSK9 polyclonal antibody; host Rabbit; reactivity Human, Rat, Mouse
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cofactor:Calcium.,disease:Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.,enzyme regulation:Inhibited by EGTA.,function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.,PTM:The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.,similarity:Belongs to the peptidase S8 family.,similarity:Contains 1 peptidase S8 domain.,subunit:The precursor protein but not the mature protein may form multimers.,tissue specificity:Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.,
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | ELISA |
|---|---|---|
| Human,Rat,Mouse |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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PCSK9 identifies proprotein convertase subtilisin/kexin type 9 in Homo sapiens (Human). This target record connects NCBI Gene 255738, UniProtKB Q8NBP7 and related ABMIUM catalogue products.
Biological function: PCSK9 is a secreted regulator of plasma cholesterol homeostasis. It binds LDL receptor-family members, including LDLR, and promotes their degradation, reducing receptor recycling to the cell surface.
