OLR1 polyclonal antibody; host Rabbit; reactivity Human, Rat, Mouse
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oxidized low density lipoprotein receptor 1(OLR1) Homo sapiens This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | ELISA |
|---|---|---|
| Human,Rat,Mouse |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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OLR1 identifies oxidized low density lipoprotein receptor 1 in Homo sapiens (Human). This target record connects NCBI Gene 4973, UniProtKB P78380 and related ABMIUM catalogue products.
Biological function: Oxidized low-density lipoprotein receptor 1 (OLR1; LOX-1) is a C-type lectin-like scavenger receptor that binds, internalizes and degrades oxidatively modified low-density lipoprotein. It is linked to endothelial dysfunction, vascular inflammation and atherosclerotic biology.
