Mesothelin polyclonal antibody; host Rabbit; reactivity Human, Rat, Mouse
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mesothelin(MSLN) Homo sapiens This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | ELISA |
|---|---|---|
| Human,Rat,Mouse |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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MSLN identifies mesothelin in Homo sapiens (Human). This target record connects NCBI Gene 10232, UniProtKB Q13421 and related ABMIUM catalogue products.
Biological function: Mesothelin (MSLN) is a glycosylphosphatidylinositol-anchored cell-surface glycoprotein produced from a precursor that is cleaved into megakaryocyte-potentiating factor and mature mesothelin. It is normally expressed on mesothelial surfaces and is widely studied as a tumour-associated cell-surface antigen.
