MCAD polyclonal antibody; host Rabbit; reactivity Human, Mouse, Rat
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acyl-CoA dehydrogenase, C-4 to C-12 straight chain(ACADM) Homo sapiens This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | ELISA |
|---|---|---|
| Human,Mouse,Rat |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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ACADM is acyl-CoA dehydrogenase medium chain, encoding mitochondrial medium-chain specific acyl-CoA dehydrogenase (MCAD). This record links the verified human identity (NCBI Gene 34; UniProt P11310) to ABMIUM catalogue products.
Biological function: Medium-chain specific acyl-CoA dehydrogenase (ACADM/MCAD) is a mitochondrial enzyme that catalyses the initial dehydrogenation step for medium-chain acyl-CoA substrates during fatty-acid beta-oxidation. It acts predominantly on approximately C4-C12 acyl-CoA chains.
