HMG-1 polyclonal antibody; host Rabbit; reactivity Human, Mouse, Rat
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high mobility group box 1(HMGB1) Homo sapiens This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | IHC-P | IF/ICC | IP | ELISA |
|---|---|---|---|---|---|
| Human,Mouse,Rat |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
HMGB1 identifies high mobility group box 1 in Homo sapiens (Human). This target record connects NCBI Gene 3146, UniProtKB P09429 and related ABMIUM catalogue products.
Biological function: HMGB1 is a multifunctional, redox-sensitive chromatin-associated protein. In the nucleus it acts as a DNA chaperone in transcription, replication, chromatin remodelling and DNA repair; extracellular or cytoplasmic HMGB1 can also participate in inflammatory and innate immune signalling.
