CD152 polyclonal antibody; host Rabbit; reactivity Human, Rat, Mouse
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cytotoxic T-lymphocyte associated protein 4(CTLA4) Homo sapiens This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | IHC-P | IF | ELISA |
|---|---|---|---|
| Human,Rat,Mouse |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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CTLA4 identifies cytotoxic T-lymphocyte associated protein 4 in Homo sapiens (Human). This target record connects NCBI Gene 1493, UniProtKB P16410 and related ABMIUM catalogue products.
Biological function: CTLA4 (CD152) is an inhibitory immune receptor expressed by activated T cells and regulatory T cells. It binds the B7 ligands CD80 and CD86 and counterbalances costimulatory signalling, limiting T-cell activation.
