Beclin-1 polyclonal antibody; host Rabbit; reactivity Human, Mouse
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beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | ELISA |
|---|---|---|
| Human,Mouse |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
BECN1 (beclin 1; Beclin-1/ATG6) is a core autophagy regulator and class III PI3K-complex component linking PI3P production to autophagosome initiation and membrane trafficking.
Biological function: Beclin-1 acts as a core subunit of class III phosphatidylinositol 3-kinase complexes that generate PI3P. Distinct BECN1-containing complexes support autophagosome initiation, autophagosome maturation and endocytic trafficking, making BECN1 central to macroautophagy and membrane-remodelling pathways.
