BACE polyclonal antibody; host Rabbit; reactivity Human, Mouse, Rat
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beta-secretase 1(BACE1) Homo sapiens This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | ELISA |
|---|---|---|
| Human,Mouse,Rat |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Beta-secretase 1 (BACE1), also known as BACE, is a membrane aspartyl protease best known for initiating beta-site processing of amyloid precursor protein (APP). This target page groups ABMIUM catalogue reagents for studying APP proteolysis, amyloid-beta pathway biology and BACE1-dependent neuronal protein processing.
Biological function: BACE1 is a type I transmembrane aspartyl protease. It cleaves APP at the beta-secretase site, generating the C99 fragment that can be further processed by gamma-secretase to produce amyloid-beta peptides. BACE1 activity is favoured in acidic intracellular compartments such as endosomes, and the enzyme also processes additional neuronal membrane proteins.
