ApoL1 polyclonal antibody; host Rabbit; reactivity Human, Rat, Mouse
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apolipoprotein L1(APOL1) Homo sapiens This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | IHC-P | IF | ELISA |
|---|---|---|---|---|
| Human,Rat,Mouse |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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Apolipoprotein L1 (APOL1; ApoL-I/APO-L) is a secreted HDL-associated protein involved in lipid-transport biology and a pore-forming component of human serum trypanosome lytic factor. It is studied in lipoprotein transport and innate trypanolytic immunity.
Biological function: Reviewed UniProt describes APOL1 as a possible participant in lipid exchange, lipid transport and reverse cholesterol transport, and as a crucial component of human trypanosome lytic factor. APOL1 forms pores in Trypanosoma brucei lysosomal membranes, contributing to parasite lysis; plasma APOL1 associates with ApoA-I-containing HDL particles.
