AMBP polyclonal antibody; host Rabbit; reactivity Human, Rat, Mouse
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alpha-1-microglobulin/bikunin precursor(AMBP) Homo sapiens This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | ELISA |
|---|---|---|
| Human,Rat,Mouse |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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AMBP (alpha-1-microglobulin/bikunin precursor) is a secreted precursor processed into alpha-1-microglobulin (A1M), an antioxidative lipocalin, and bikunin, a serine-protease inhibitor. It is studied in extracellular oxidative-stress control, protease regulation and inter-alpha-inhibitor biology.
Biological function: Proteolytic processing of AMBP produces two functionally distinct proteins. Alpha-1-microglobulin binds and scavenges heme and reactive radicals and contributes to protection from oxidative tissue damage. Bikunin inhibits several serine proteases and contributes to inter-alpha-trypsin inhibitor family complexes in extracellular protease regulation.
