AL7A1 polyclonal antibody; host Rabbit; reactivity Human, Mouse, Rat
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The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. [provided by RefSeq, Jan 2011],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB |
|---|---|
| Human,Mouse,Rat |
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ALDH7A1 (aldehyde dehydrogenase 7 family member A1), also known as alpha-aminoadipic semialdehyde dehydrogenase or antiquitin, is a cytosolic and mitochondrial aldehyde dehydrogenase. Researchers study ALDH7A1 in aldehyde detoxification, lysine-degradation biology and pyridoxine-dependent epilepsy.
Biological function: ALDH7A1 is an aldehyde dehydrogenase with cytosolic and mitochondrial isoforms. It protects cells from oxidative stress by metabolising lipid-peroxidation-derived aldehydes and is also linked to the alpha-aminoadipic semialdehyde step of human lysine degradation.
