Akt3 polyclonal antibody; host Rabbit; reactivity Human, Mouse, Rat
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AKT serine/threonine kinase 3(AKT3) Homo sapiens The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB |
|---|---|
| Human,Mouse,Rat |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
AKT3 encodes AKT serine/threonine kinase 3, whose reviewed human protein is RAC-gamma serine/threonine-protein kinase (protein kinase B gamma/PKB gamma). It is one of the three AKT kinases that couple growth-factor signalling to phosphorylation programmes controlling cell survival, growth, metabolism and proliferation.
Biological function: AKT3 is a serine/threonine kinase activated within PI3K-AKT signalling. Reviewed UniProt describes AKT3 as phosphorylating downstream substrates that regulate metabolism, proliferation, survival, growth and angiogenesis. Compared with AKT1 and AKT2, AKT3 is less extensively characterised and has particularly important roles in brain development.
