AHR polyclonal antibody; host Rabbit; reactivity Human, Mouse, Rat
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aryl hydrocarbon receptor(AHR) Homo sapiens The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB |
|---|---|
| Human,Mouse,Rat |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
AHR is the aryl hydrocarbon receptor, also known as AhR or Ah receptor. This ligand-activated transcription factor senses diverse environmental, dietary, microbial and endogenous compounds and converts ligand binding into regulated gene-expression programmes.
Biological function: AHR is a ligand-activated basic helix-loop-helix transcription factor. After ligand binding it translocates to the nucleus, heterodimerizes with ARNT and binds xenobiotic-response elements to regulate target genes, including xenobiotic-metabolising enzymes such as CYP1A1. AHR signalling also contributes to broader developmental, metabolic and immune regulatory programmes.
